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One of the fundamental skills required for practising EBM is the asking of well-built clinical questions. To benefit patients and clinicians, such questions need to be both directly relevant to patients’ problems and phrased in ways that direct your search to relevant and precise answers. In practice, well-built clinical questions usually contain four elements, summarised below.
Focused ultrasound (FUS) is a promising intervention for BBB disruption that has been widely studied across preclinical brain tumor models with promising results, and initial studies in brain tumor patients are underway. Here, we will discuss the mechanism of FUS, preclinical evidence, and clinical studies that used low-frequency FUS for BBB in. I'm trying to create an auto-complete list that appears as you type, but disappears when you click elsewhere on the document. How do I detect that a form input is focused using Angular 2. Angular 1 has ng-focus, but I don't think Angular 2 supports that anymore.
- A total of 81 patients with at least one type 2 submucosal fibroid were enrolled. The mean diameter of type 2 submucosal fibroids was 3.8 ± 0.9 cm (range: 2.0-5.0 cm) for 39 patients in the FUS group and 3.5 ± 0.8 cm (range: 2.0-4.8 cm) for the 42 patients enrolled in the TCRM group.
- Type 3 ADD is often found in substance abusers as well as in the children and grandchildren of alcoholics. Implementing these six tips will help you manage the symptoms of ADD Type 3: Boost Your Levels: One way to treat Over-Focused ADD is to increase the dopamine and serotonin levels in the brain. The best way to boost both is with exercise.
| 1 | 2 | 3 | 4 | |
|---|---|---|---|---|
| Patient or Problem | Intervention (a cause, prognostic factor, treatment, etc.) | Comparison Intervention (if necessary) | Outcomes | |
| Tips for Building | Starting with your patient, ask “How would I describe a group of patients similar to mine?” Balance precision with brevity. | Ask “Which main intervention am I considering?”Be specific. | Ask “What is the main alternative to compare with the intervention?”Again, be specific. | Ask “What can I hope to accomplish?” or “What could this exposure really affect?”Again, be specific. |
| Example | “In patients with heart failure from dilated cardiomyopathy who are in sinus rhythm …” | “… would adding anticoagulation with warfarin to standard heart failure therapy …” | “… when compared with standard therapy alone …” | “… lead to lower mortality or morbidity from thromboembolism. Is this enough to be worth the increased risk of bleeding?” |
Focused (was Typed) 2 2 Esv
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Educational Prescription (PDF)
Benefits of asking focused questions
One of the benefits of careful and thoughtful question-forming is that the search for evidence is easier. The well-formed question makes it relatively straightforward to elicit and combine the appropriate terms needed to represent your need for information in the query language of whichever searching service is available to you.
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Once you have formed the question using the PICO structure, you can think about what type of question it is you are asking, and therefore what type of research would provide the best answer.