Hazel 4 0 5
What’s New in Hazel 4. Hazel 4 brings in new features to make it easier to create and maintain rules. And of course, there’s more to discover. View the release notes, download it yourself and start exploring. Join our mailing list and keep up with major updates and news. April 5, 1962 Hazel organizes a pajama party for Linda (Brenda Scott), the daughter of the Baxters' new neighbors, the Blakes. When Hazel is not invited to the girl's party, George and Dorothy have their own slumber party for her. The girls next door hear all the fun that. Pip install hazel0.4.5 SourceRank 7. Dependencies 0 Dependent packages 0 Dependent repositories 1 Total releases 5 Latest release May 24, 2013 First release May 17, 2013 Stars 2 Forks 0 Watchers 2 Contributors 1 Repository size 462 KB Documentation.
Scientific Name(s): Corylus americana Walter (American hazel)., Corylus avellana L. (common hazel)., Corylus colurna L. (Turkish hazel).
Common Name(s): Dukkah, Filbert, Hazelnut
Medically reviewed by Drugs.com. Last updated on Mar 20, 2020.
Clinical Overview
Use
Hazelnuts (raw, roasted, or ground into a paste) are used as a dietary source of protein and minerals. They are a source of vitamin E, unsaturated fatty acids, and linolenic acid. Hazelnut oil also is used in the cosmetic industry as well as in confectionery.
Dosing
There are inadequate data to support dosing for therapeutic effect. Approximately 100 g of nuts delivers 15 mg of vitamin E.
Contraindications
Allergy to tree nuts or their products. Use caution in patients with known allergy to peanuts.
Pregnancy/Lactation
Information regarding safety and efficacy during pregnancy and lactation is lacking. Consumption of hazelnuts is generally recognized as safe when used as a food. No teratogenicity studies specific to hazelnut have been found.
Interactions
None well documented.
Adverse Reactions
Cross-reactivity with other tree nuts and co-allergy with peanuts have been described.
Toxicology
A review by the Cosmetic Ingredient Review Expert Panel concluded there are insufficient data to support the safety of hazelnut oil in cosmetic products. Carcinogenic aflatoxins are possible contaminants of hazelnuts.
Scientific Family
- Betulaceae (birch)
Botany
The genus Corylus includes at least 11 species of hazel trees and hybrids also exist.1 The trees grow from 3 to 8 m in height and were probably introduced into North America from Europe. Turkey is the leading producer of hazelnuts in the world.2 The deciduous trees bear large (6 to 12 cm) rounded leaves with soft hairs on both surfaces and a doubly serrate margin. The tree flowers in early spring before the leaves develop, and the nuts hang in clusters of 1 to 5. A 'husk' encloses 75% of the yellow-brown, spherical/oval nut, leaving a scar at the base of the hazelnut kernel.1
Hazel 4 0 5 X 4
History
In addition to consumption of the nuts as a source of protein, the leaves of the hazel tree have been used in folk medicine to relieve hemorrhoidal symptoms and varicose veins caused by purported vasoconstrictor properties.3
Chemistry
The minerals of the nut include calcium, copper, iron, magnesium, manganese, phosphorus, selenium, and zinc; vitamins include alpha-tocopherol, ascorbic acid, folates, niacin, riboflavin, thiamin, and vitamin K as phylloquinone; fatty and amino acids include alanine, arginine, aspartic acid, glutamic acid, and leucine.2, 4, 5
Tocopherol composition remains fairly consistent across geographic distribution and harvesting period.6 The hazelnut is the best dietary nut source of alpha-tocopherol, containing 2 to 3 times more than olive oil.7
The kernels contain about 60% seed oil2, 7 which is derived by cold pressing. The oil contains saturated fatty acids (7%), mono- (78%) and polyunsaturated fatty acids (10%), and phytosterols (0.1%).5, 8 Composition of the oil varies with geographic origin8; however, roasting the nuts prior to compressing appears to have little or no effect on oil composition.2, 9
Oleic, linoleic, linolenic, palmitoleic, and steric fatty acids are found in the oil.2, 7, 10 Beta-sitosterol, campesterol, avenasterol, and clerosterol sterols have been identified, and their concentrations are dependent on geographic origin and harvesting period.2, 7, 8
Caffeoylquinic acid, caffeoyltartaric acid, coumaroyltartaric acid, myricetin, quercetin, and kaempferol phenols are found in hazel leaves, where 3, 11 tannins also have been identified.11
Uses and Pharmacology
Hazelnuts are a dietary source of protein, unsaturated fats, minerals and micronutrients, phytochemicals, alpha-tocopherol, and fiber; they are considered a good source of tocopherol when used to meet the recommended daily allowance for vitamin E.4, 7, 12
Dyslipidemia
Animal data
Rabbits fed a high-cholesterol diet and concurrent hazelnut oil maintained their baseline lipid profiles. No effect of hazelnut oil on the lipid profile was found in the control rabbits fed a normal diet. Hazelnut oil was also protective against atherosclerotic plaque formation upon histological examination.13
Clinical data
Results from a small stud revealed that hazelnut supplementation of 1 g/kg body weight/day showed reduced low-density lipoprotein and total cholesterol and increased high-density lipoprotein and triglycerides.12 Researchers have demonstrated improved lipid profiles (increased HDL and decreased LDL-C and total-C:HDL-C ratio) with hazelnut supplementation.14, 15
Trials and epidemiological studies have found the consumption of nuts to be protective against cardiac morbidity and mortality. The Physicians' Health Study, a large prospective cohort study of United States physicians, associated dietary nut intake with a reduced risk of sudden cardiac death (47% lower risk for those who consumed nuts 2 or more times a week) but did not find it protective against nonfatal myocardial infarction.16
Assessment of data from 6,705 participants without baseline atrial fibrillation in the PREDIMED trial revealed a significant relevant reduction in risk of atrial fibrillation (38%) with the Mediterranean diet supplemented with extravirgin olive oil (50 g/day or more) but not with the Mediterranean diet supplemented with nuts (almonds, hazelnuts, walnuts).17
As a component of medical nutrition therapy for patients with type 2 diabetes, the American Diabetes Association Standards of Care (2014) recommend higher quality dietary fat intake, as an alternative to decreased fat intake, by replacing saturated and/or trans fats with mono- and poly-unsaturated fatty acids in the diet. This Mediterranean-style approach to eating may improve glycemic control and cardiovascular disease risk factors (moderate-quality evidence).18
Other uses
Hazel 4 0 5 Sezonas
Antioxidant activity and radical scavenging properties of the kernel and green leaf/flower portions of the hazel tree have been demonstrated.11 In doxorubicin-induced cataracts in rats, the administration of hazelnut was protective in lower-dose doxorubicin; hazelnut did not prevent cataracts at higher doses of doxorubicin. Because doxorubicin causes oxidative stress to cells, the anticataract effect is considered to be due to the antioxidant action of vitamin E and other elements found in the hazelnut (eg, copper, iron, selenium, zinc).19
An antiprostaglandin/anti-inflammatory action has been described.20
Dosing
There are inadequate data to support dosing for therapeutic effect. One human trial used hazelnuts 1 g/kg body weight/day.12 The recommended daily amount of 15 mg vitamin E would be contained in approximately 100 g of nuts.5
A clinical study has demonstrated acceptability of 30g hazelnuts daily, but not 60g daily.21, 22
Pregnancy / Lactation
Information regarding safety and efficacy during pregnancy and lactation is lacking.
Interactions
None documented.
Adverse Reactions
Allergies to nuts are common in the United States (estimated 1%)23; however, cross-reactivity to the proteins from tree nuts (hazelnut) among people with peanut (legume) allergies is considered low. Rather, a co-allergy is probably the cause of allergic reactions among these atopic individuals. Cross-reactivity between hazelnut and Brazil nut has been documented; similar proteins are found in the nuts of these botanically distinct trees.24, 25
Anaphylaxis, urticaria, vomiting, and wheezing have been reported in response to hazelnut consumption. Immunoglobulin E (mast cell) and T-cell (cytokine) responses are described. Because sensitization is required, the possibility of these responses occurring in utero or via breast milk has been postulated, but no high-quality studies exist to support this theory.24 Oral desensitization to hazelnut may offer partial protection.23
The use of antiulcer drugs is another possible method of sensitization to hazelnut. Hazelnut allergens are not resistant to gastric and pancreatic acid digestion, and the use of famotidine, omeprazole, ranitidine, and sucralfate in animal and human experiments displayed some evidence of this effect.26
Toxicology
Placental transfer of fatty acids has been documented, but no teratogenicity studies specific to hazelnut have been found.10
A review by the Cosmetic Ingredient Review Expert Panel concluded there are insufficient data to support safety of hazelnut oil in cosmetic products.10
Aflatoxins are considered carcinogenic and are possible contaminants of hazelnuts.10
References
Disclaimer
This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.
This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.
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Further information
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Motivation
When programming, we spend a substantial amount of our time working with program text that is not yet a formally complete program, e.g. because there are blank spots, type errors or merge conflicts at various locations. Conventional programming language definitions assign no formal meaning to structures like these, so program editors and other tools have no choice but to resort to complex and ad hoc heuristics to provide various useful language services (like code completion, type inspection, code navigation, and live programming services) without gaps in service.
We are developing a more principled approach to working with incomplete programs, rooted in (contextual modal and gradual) type theory. We model incomplete programs as programs with holes, which (1) stand for parts of the program that are missing; and (2) serve as membranes around parts of the program that are erroneous or, in the collaborative setting, conflicted.
We are implementing these ideas into Hazel, a web-based programming environment for an Elm/ML-like functional programming language being designed from the ground up around typed hole-driven development.
Uniquely, every incomplete program that you can construct using Hazel's language of type-aware edit actions is both statically and dynamically well-defined, i.e. it has a (possibly incomplete) type, and you can run it to produce a (possibly incomplete) result. Consequently, Hazel serves as an elegant platform for research on the future of programming.
The following paper describes our research vision in more detail.
SNAPL 2017 [.bib] [slides]